Scientists produce genetically engineered, cloned pigs for xenotransplantation

BMJ 2002; 324 doi: (Published 12 January 2002) Cite this as: BMJ 2002;324:70
  1. Roger Dobson
  1. Abergavenny

    Two groups of scientists have produced genetically engineered, cloned pigs whose tissue may be suitable for transplanting into humans. Both teams have reported having bred pigs that lack the gene that causes rejection.

    PPL Therapeutics, which is based in Edinburgh, has produced five pigs that lack the gene, while Immerge BioTherapeutics and a team from the University of Missouri-Columbia have cloned miniature pigs with the gene “knocked out” of their DNA.

    “With one of the major technical hurdles and scientific risks overcome, the promise of xenotransplantation is now a reality, with the potential to revolutionise the transplant industry,” said …

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