Managing a suspected adverse drug reaction

Frequency and types of adverse drug reaction

ADRs are common. In a recent single practice study general practitioners estimated that the presenting symptom of 1.7% of their consultations over a six month period was a manifestation of an ADR.1 Furthermore, it is likely that 2-6% of hospital admissions are for ADRs.2 Both these figures may underestimate the true incidence.

Any drug may cause a reaction. In broad terms, ADRs may be considered in five groups. The two most common are dose related effects (type A: augmented) and effects related to abnormal interaction between patient and drug (type B: bizarre). Postural hypotension in a patient on antihypertensive …