Second diphtheria booster in adults raises immunity to 92%

BMJ 2001; 323 doi: https://doi.org/10.1136/bmj.323.7324.1308 (Published 01 December 2001) Cite this as: BMJ 2001;323:1308
  1. Akke Vellinga (akkevel@uia.ua.ac.be), epidemiologist,
  2. Pierre Van Damme, researcher,
  3. Els Joosens, assistant,
  4. Marie van der Wielen, assistant,
  5. Herman Goossens, professor
  1. Centre for the Evaluation of Vaccination, Department of Epidemiology and Community Medicine, University of Antwerp, 2610 Antwerp, Belgium
  2. Laboratory of Microbiology, University of Antwerp

    EDITOR—After assessing the antibody response to one diphtheria booster vaccination in adults1 we conducted a second part of the trial to determine the effect of giving a second booster dose. Of the 176 volunteers whom we originally recruited, 141 cooperated (mean age 41.0 (SD 4.0) years). After a blood sample was taken at month 6, a second booster was given. An additional blood sample was taken a month later. The methods and results of the first part of the trial …

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