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Prenatal growth and risk of occlusive and haemorrhagic stroke in Swedish men and women born 1915-29: historical cohort study

BMJ 2001; 323 doi: https://doi.org/10.1136/bmj.323.7320.1033 (Published 03 November 2001) Cite this as: BMJ 2001;323:1033

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Don't forget genetic factors

Hypponen et al report an increased risk of haemorrhagic stroke with
impaired fetal growth. They controlled for basic growth parameters and
gestation to confirm the reduced growth but no mention is made of genetic
factors.

Were siblings also small for dates?

Has any first degree relative also experienced a haemorrhagic, or
occlusive, stroke?

Surely these would be factors of prime importance in the aetiology of
the association - presumably the purpose of this enquiry?

Competing interests: No competing interests

27 November 2001
Diana Wellesley
Head of Prenatal Genetics
Wessex Clinial Genetics Service, Princess Anne Hospital, Southampton SO16 5YA
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