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Thyroxine treatment in patients with symptoms of hypothyroidism but thyroid function tests within the reference range: randomised double blind placebo controlled crossover trial

BMJ 2001; 323 doi: https://doi.org/10.1136/bmj.323.7318.891 (Published 20 October 2001) Cite this as: BMJ 2001;323:891

Data supplement

  • Table A

    Table B
     

    Table A Baseline characteristics of patients with symptoms of hypothyroidism but thyroid function tests within the reference range and for controls. Values are means (SD) except for numbers

       
      Patients (n=25)
      Controls (n=19)
      No of men/women
      2/23
      2/17
      Age (years)
      47.6 (11.4)
      48.9 (10.4)
      Previous thyroxine treatment (n)
      3
      0
      Previous psychiatric contact (n)
      6
      1
      Referral:
      General practitioner (n)
      13
      NA
      Self referral (n)
      9
      NA
      Other (n)
      3
      NA
      Free thyroxine (pmol/l)
      13.3 (2.1)
      14.2 (2.1)
      Free triiodothyronine (pmol/l)
      3.0 (0.67)
      3.4 (0.60)
      Thyroid stimulating hormone (mU/l) at 0 mins
      1.9 (1.1)
      1.4 (0.9)
      Thyroid stimulating hormone(mU/l) at 20 mins
      14.6 (9.5)
      13.1 (6.9)
      Cholesterol (mmol/l)
      6.3 (1.3)
      5.2 (0.86)
      Prolactin (mU/l)
      312 (199)
      233 (116)
      Ferritin (ng/l)
      61 (43)
      57 (54)
      Antithyroid peroxidase antibodies (U/ml)
      184 (450)
      32 (58)
      Weight (kg)
      85 (20)
      67 (12)
      Pulse (beats/min)
      79 (15)
      72 (11)
      Diastolic blood pressure (mm Hg)
      81 (12)
      77 (9)

      NA=not applicable.
       

      Table B Scores on psychological assessment measures at baseline for patients with symptoms of hypothyroidism but thyroid function tests within the reference range and for controls. Values are means (SD)

         
        Patients
        (n=25)
        Controls
        (n=19)
        P value
        Cognitive functioning
        Logical memory I
        18.68 (5.88)
        29.11 (6.03)
        <0.001
        Logical memory II
        15.09 (6.58)
        25.63 (7.60)
        <0.001
        Verbal paired associates I
        15.86 (3.54)
        19.00 (3.00)
        NS
        Verbal paired associates II
        6.45 (1.34)
        6.95 (1.18)
        NS
        Visual reproduction I
        30.00 (6.58)
        33.89 (3.81)
        NS
        Visual reproduction II
        25.32 (7.07)
        31.74 (5.82)
        NS
        Digits forward
        8.55 (1.57)
        9.00 (2.31)
        NS
        Digits backward
        6.95 (2.30)
        8.11 (2.79)
        NS
        Trail making test
        97.50 (39.97)
        61.68 (16.99)
        0.001
        Psychological functioning and physical health
        Hospital anxiety and depression scale
        20.91 (8.74)
        8.37 (5.04)
        <0.001
        SF-36 health survey:  
         
         
        Role emotional
        33.33 (44.84)
        82.45 (35.78)
        <0.001
        Physical functioning
        35.91 (30.69)
        87.50 (18.62)
        <0.001
        Role physical
        13.64 (30.06)
        84.21 (26.63)
        <0.001
        General health
        37.50 (24.10)
        84.79 (14.08)
        <0.001
        Vitality
        26.60 (22.06)
        64.47 (17.79)
        <0.001

        NS=not significant.
         

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