Predictive genetics and predictive morphology have certain similarities

BMJ 2001; 323 doi: https://doi.org/10.1136/bmj.323.7311.514 (Published 01 September 2001) Cite this as: BMJ 2001;323:514
  1. Elliott Foucar, pathologist (foucell@aol.com)
  1. Department of Pathology, Presbyterian Hospital, Albuquerque, NM 87106, USA

    EDITOR—Evans et al may be exaggerating the distinction between genetic predictive testing and predictive testing based on various phenotypic abnormalities.1 Phenotypic predictive testing, such as grading the histopathological abnormalities in breast ducts, is often performed on tissue from clinically well patients.

    Genetic and histopathological tests use different methodologies to search for the presence of cellular structural abnormalities that are useful for risk assessment in asymptomatic patients. Both types of test, though, carry a degree of uncertainty …

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