High dose methylprednisolone must be given for 24 or 48 hours after acute spinal cord injury

BMJ 2001; 322 doi: https://doi.org/10.1136/bmj.322.7290.862/b (Published 07 April 2001) Cite this as: BMJ 2001;322:862
  1. Michael B Bracken (michael.bracken@yale.edu), professor of epidemiology and neurology
  1. Yale University School of Medicine, Department of Epidemiology and Public Health, PO Box 208034, New Haven, CT 06520-8034, USA

    EDITOR—Short's letter about the use of steroids for acute spinal cord injury1 leads me to question the quality of the purported systematic review that she and colleagues carried out. Trials were missed, and the authors relied heavily on uncontrolled or historically controlled case series and seemed to depend on cat experiments to evaluate risk of mortality.

    Since the original trial of high dose methylprednisolone was published2 it has been repeatedly documented that the …

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