Could fewer islet cells be transplanted in type 1 diabetes?

BMJ 2001; 322 doi: https://doi.org/10.1136/bmj.322.7290.861 (Published 07 April 2001) Cite this as: BMJ 2001;322:861

Insulin independence should be dominant force in islet transplantation

  1. James Shapiro (amjs@powersurfr.com), Hunterian professor of surgery, department of surgery,
  2. Edmond Ryan, associate professor of medicine, department of medicine,
  3. Garth L Warnock, professor of surgery, department of surgery,
  4. Norman M Kneteman, professor of surgery, department of surgery,
  5. Jonathan Lakey, assistant professor of surgery,
  6. Gregory S Korbutt, associate professor of surgery,
  7. Ray V Rajotte, professor of medicine and surgery
  1. 8440 112th Street, University of Alberta, Edmonton, Alberta, Canada T6G 2B7
  2. Surgical-Medical Research Institute, 1074 Dentistry-Pharmacy Building, University of Alberta, Edmonton, Alberta Canada T6G 2N8
  3. Southampton Health Technology Assessments Centre, Wessex Institute, University of Southampton SO16 7PX

    EDITOR—Waugh is correct in saying that demand for islet transplantation will exceed supply and the ratio of risk to benefit should be balanced for the individual patient.1 Balancing the societal benefit of cost and utility hinges more on the definition of success. Accepting glucose stability rather than insulin independence has been discussed among our group but in the first instance we believe that freedom from insulin should be the goal. Unfortunately, the fact that few patients given islet transplants during the past …

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