Tobacco industry must not dump its high nitrosamine tobacco on poor countries
BMJ 2001; 322 doi: https://doi.org/10.1136/bmj.322.7285.557/a (Published 03 March 2001) Cite this as: BMJ 2001;322:557- Nigel Gray, senior research associatea,
- Peter Boyle, director
- Division of Epidemiology and Biostatistics, European Institute of Oncology, 20141, Milan, Italy
EDITOR—In the late 1970s Hoffmann's group described the carcinogenic properties of the tobacco-specific nitrosamines including 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine in a series of experiments.1 These substances are formed during the curing process by a chemical reaction between nicotine and nitrate. They are present in cigarettes, chewing tobacco, and snuff. One of the substances, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone, is of particular interest as it is a powerful lung adenocarcinogen in animals regardless of route of administration. Adducts of N'-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone are seen in …
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