Tobacco industry must not dump its high nitrosamine tobacco on poor countries

BMJ 2001; 322 doi: https://doi.org/10.1136/bmj.322.7285.557/a (Published 03 March 2001) Cite this as: BMJ 2001;322:557
  1. Nigel Gray, senior research associatea,
  2. Peter Boyle, director
  1. Division of Epidemiology and Biostatistics, European Institute of Oncology, 20141, Milan, Italy

    EDITOR—In the late 1970s Hoffmann's group described the carcinogenic properties of the tobacco-specific nitrosamines including 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine in a series of experiments.1 These substances are formed during the curing process by a chemical reaction between nicotine and nitrate. They are present in cigarettes, chewing tobacco, and snuff. One of the substances, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone, is of particular interest as it is a powerful lung adenocarcinogen in animals regardless of route of administration. Adducts of N'-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone are seen in …

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