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Apparent interaction between warfarin and levonorgestrel used for emergency contraception

BMJ 2000; 321 doi: (Published 02 December 2000) Cite this as: BMJ 2000;321:1382
  1. J Ellison,
  2. A J Thomson,
  3. I A Greer,
  4. I D Walker
  1. Department of Obstetrics and Gynaecology
  2. Department of Haematology, Glasgow Royal Infirmary, Glasgow G31 2ER

    Emergency contraception with progestogen only (two doses of levonorgestrel 0.75 mg given 12 hours apart and within 72 hours of unprotected intercourse) is better tolerated and more effective than the combined oestrogen-progestogen (Yuzpe) regimen.1 Furthermore, treatment with progestogen only may be preferable to the Yuzpe regimen in women with a known thrombophilic defect or history of thromboembolic events. For women receiving warfarin, drug information cites either no interaction between progestogens and warfarin2 or a …

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