Intended for healthcare professionals


Persistence of tuberculosis explained

BMJ 2000; 321 doi: (Published 19 August 2000) Cite this as: BMJ 2000;321:469
  1. Abi Berger
  1. BMJ

    A critical biochemical pathway explains how bacteria that cause tuberculosis are able to lie dormant for years before causing active infection. American scientists have identified the secret that allows Mycobacterium tuberculosis to persist subclinically, without causing overt infection. This discovery shows new targets for anti-tuberculosis drug treatment and may dramatically shorten the length of time required for treatment (Nature 2000;406:735-8).

    According to Dr Bill Jacobs, one of the collaborating scientists who is based at the Albert Einstein College …

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