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I recently proposed that the enzyme 'Tubulin Tyrosine Ligase' (TTL)
may supress tumors by enhancing tubulin nitrotyrosination, leading to
microtubule dysfunction and therefore cell death (Idriss, HT. Nitric
Oxide, 4:1-3). Many tumor cells seem to have suprressed levels of TTL and
therefore may escape tubulin nitrotyrosination-mediated cytotoxicity. I
was wondering if gene therapy of TTL could ultimately lead to tumor
shrinkage, perhaps when complemented with Tumor Necrosis Factor (TNF)
adminstration.
Could Delivery of Tubulin Tyrosine Ligase Supress Tumors
Dear Sir,
I recently proposed that the enzyme 'Tubulin Tyrosine Ligase' (TTL)
may supress tumors by enhancing tubulin nitrotyrosination, leading to
microtubule dysfunction and therefore cell death (Idriss, HT. Nitric
Oxide, 4:1-3). Many tumor cells seem to have suprressed levels of TTL and
therefore may escape tubulin nitrotyrosination-mediated cytotoxicity. I
was wondering if gene therapy of TTL could ultimately lead to tumor
shrinkage, perhaps when complemented with Tumor Necrosis Factor (TNF)
adminstration.
Maybe worth considering!
Haitham Idriss.
Competing interests: No competing interests