Intended for healthcare professionals


Cancer drug may cause heart failure

BMJ 2000; 321 doi: (Published 29 July 2000) Cite this as: BMJ 2000;321:259
  1. Scott Gottlieb
  1. New York

    A team of researchers is calling for long term studies investigating the risk of heart failure among women taking the breast cancer drug trastuzumab (Herceptin) as a result of new evidence that the drug might precipitate heart failure, especially in women with underlying cardiovascular problems.

    Trastuzumab is a monoclonal antibody that binds to a protein found on the surface of some cells. The protein, HER2, helps to regulate cell growth. By binding to tumour cells, trastuzumab inhibits the growth of cancerous cells. …

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