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This Week In The Bmj

Long allele α oestrogen receptor genotype may increase risk of coronary artery disease

BMJ 2000; 321 doi: https://doi.org/10.1136/bmj.321.7256.0/d (Published 29 July 2000) Cite this as: BMJ 2000;321:d

The risk of coronary artery disease has been linked to concentrations of oestrogen and the density of oestrogen receptors as well as a host of other factors. Kunnas et al (p 273) carried out a case control study in 119 patients with myocardial infarction to determine the effect of the α oestrogen receptor genotype on the severity of the infarction. Compared with patients with short alleles, those with long alleles for the α oestrogen receptor were at a greater risk of myocardial infarction (OR=11.4), with greater coronary narrowing and more complicated lesions. They speculate that carriers of long repeat variants have lower expression of the oestrogen receptor gene and benefit less from the cardiovascular protective effect of oestrogen receptors.

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