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Ibuprofen useful in treating babies' heart defect

BMJ 2000; 321 doi: (Published 22 July 2000) Cite this as: BMJ 2000;321:198
  1. Scott Gottlieb
  1. New York

    Ibuprofen works just as well as indomethacin for non-surgical closure of patent ductus arteriosus in premature babies and is less likely to cause dangerous side effects, according to a new study.

    The New England Journal of Medicine released the study on its website in advance of its publication date because of its potential in benefiting clinical practice (

    The ductus arteriosus is a wide, muscular blood vessel joining the pulmonary artery and the aorta. This connection allows blood to be diverted from the lungs into the aorta during fetal development as the baby does not breathe until after delivery. …

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