Altering a gene in mice prevents obesity

In research that may lead to the development of novel treatments for obesity in humans, scientists have found a single gene in a group of mice that, once altered, allows the animals to eat a glutinous, high fat diet without gaining weight, according to a new study (Nature Genetics 2000;24:377-80).

In its normal form the gene, called HMGIC, helps mice make more cells to store fat when they have been eating a fatty …