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Seasonality of birth in children with diabetes

BMJ 2000; 320 doi: (Published 11 March 2000) Cite this as: BMJ 2000;320:716

Results of various studies differ

  1. Hongxin Zhao, research student (,
  2. Andrew G Demaine, senior lecturer,
  3. B Ann Millward, consultant diabetologist
  1. Molecular Medicine Research Group, Plymouth Postgraduate Medical School, University of Plymouth, Plymouth PL6 8BX
  2. WHO Collaborating Centre for the Study of Diabetes in Youth, Endocrinology and Diabetes Research Unit, Schneider Children's Medical Centre of Israel, Petah Tikva 49202, Israel

    EDITOR—Rothwell et al have found evidence for seasonality of birth in children with diabetes from Great Britain but not elsewhere.1 They do not, however, give ascertainment estimates for the centres participating in the study. Consequently, selection bias may play a part in their results, particularly in those centres with low case ascertainments.

    Although this is a large multicentre study, the authors have not analysed the pooled data. They point out that sample sizes from many centres were too small to provide enough power for the seasonality of birth in these children to …

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