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New test may improve methods for detecting recurrence of colon cancer

BMJ 1999; 319 doi: (Published 18 December 1999) Cite this as: BMJ 1999;319:1592
  1. Scott Gottlieb
  1. New York

    In patients with apparently node negative colorectal cancer, the presence of a specific protein may be a more accurate marker of recurrence after surgical resection than currently used markers, according to the results of a new study.

    The lead author, Dr Scott Waldman, and his colleagues at Thomas Jefferson University in Philadelphia looked at 21 patients with histologically confirmed node negative colorectal cancer who had undergone resection. Sections of paraffin-embedded lymph nodes were obtained from each patient and were pooled, and their RNA was analysed by reverse transcriptase polymerase chain reaction.

    The protein known as guanylyl cyclase C messenger RNA (GCC …

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