Papers
Hypericum extract versus imipramine or placebo in patients with moderate depression: randomised multicentre study of treatment for eight weeksCommentary: Has hypericum found its place in antidepressant treatment?
BMJ 1999; 319 doi: https://doi.org/10.1136/bmj.319.7224.1534 (Published 11 December 1999) Cite this as: BMJ 1999;319:1534
Data supplement
Sample size calculationThe sample size (100 in the active treatment groups and 40 in the placebo group) was estimated according to the following variables: primary endpoint change from baseline on Hamilton depression total score; assumption of improvement in the placebo group by nine points, improvement in the active drug groups by 12 points, and standard deviation of changes by 6 points; a minimum important difference for comparison between hypericum extract v placebo: d>0.5 (d is difference between both treatments divided by standard deviations; non-inferior difference for comparison between hypericum extract v imipramine: d£ 0.35; and α =0.025 (one sided), 1-β =0.80.
Flow of participants
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