COX 2 inhibitors can affect the stomach liningBMJ 1999; 319 doi: https://doi.org/10.1136/bmj.319.7224.1518 (Published 11 December 1999) Cite this as: BMJ 1999;319:1518
- Deborah Josefson
- San Francisco
A new class of analgesics designed to be less ulcerogenic than traditional non-steroidal anti-inflammatory drugs may not protect the gastric lining after all, according to a University of California study (Nature Medicine 1999;5:1415-23, 1348-9).
Their ulcerogenic effect may stem from their antiangiogenic properties, and as such they may be useful anticancer drugs.
The analgesics, agents known as selective cyclo-oxygenase-2 (COX 2) inhibitors, were specifically designed to be less harmful to the gastric mucosal …