Intended for healthcare professionals


COX 2 inhibitors can affect the stomach lining

BMJ 1999; 319 doi: (Published 11 December 1999) Cite this as: BMJ 1999;319:1518
  1. Deborah Josefson
  1. San Francisco

    A new class of analgesics designed to be less ulcerogenic than traditional non-steroidal anti-inflammatory drugs may not protect the gastric lining after all, according to a University of California study (Nature Medicine 1999;5:1415-23, 1348-9).

    Their ulcerogenic effect may stem from their antiangiogenic properties, and as such they may be useful anticancer drugs.

    The analgesics, agents known as selective cyclo-oxygenase-2 (COX 2) inhibitors, were specifically designed to be less harmful to the gastric mucosal …

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