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Cost effectiveness analysis of inhaled anticholinergics for acute childhood and adolescent asthma

BMJ 1999; 319 doi: https://doi.org/10.1136/bmj.319.7223.1470 (Published 04 December 1999) Cite this as: BMJ 1999;319:1470

Data supplement

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    Values and distributions used for sensitivity analysis

    Value in baseline analysisRange of values for univariate sensitivity analysisDistribution for probabilistic sensitivity analysisSource of data
    Risk difference0.0940.004 to 0.184 (95% CI)Normal with mean 0.094 and standard error 0.0464Meta-analysis from Cochrane review, multiple dose comparison, fixed effects model1
    Dose of ipratropium0.625 mg0.25 mg to 1 mgUniform between 0.25 mg and 1 mgRange of values used in trials included in multiple dose comparison1
    Unit cost of ipratropium£0.25 per 0.25 mg£0.16 to £0.34Uniform between £0.16 and £0.34Range of NHS net prices for various non-proprietary and branded formulations from British National Formulary, March 1999.
    Cost per inpatient admission, acute asthma£860£620 to £907 (interquartile range)Normal with mean £860 and standard error £40Distribution for 236 English hospital trusts reported in the NHS Executive 1998 national reference cost list for HRG D21 and D22 for non-elective inpatients
    Annual asthma admissions from casualty, acute asthma, age 5-15, England72006570 to 7820 (95% CI)Normal with mean 7200 and standard error 320.Hospital episode statistics data for England, 1988 to 1996
    Percentage of casualty attendees (age 5-15 with acute asthma) admitted40%30% to 50%Uniform between 30% and 50%Mean rate estimated from an audit of UK accident and emergency departments4 (range estimated by authors)
    Percentage of casualty attendees (age 5-15 with acute asthma) in severe category50%25% to 75%Uniform distribution between 25% and 75%Estimated by authors based on an audit of asthma attenders in accident and emergency at a UK hospital over two years5 (severity defined by British Thoracic Society guidelines)
    Annual additional percentage uptake of review recommendations5%5% to 20%Not includedEstimated by authors
    Discount rate6%3% to 6%Not includedStandard UK rate (6%) and recommended US rate (3%)

    CI=confidence interval.

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