The effectiveness of glucocorticoids in treating croup: meta-analysisBMJ 1999; 319 doi: https://doi.org/10.1136/bmj.319.7210.595 (Published 04 September 1999) Cite this as: BMJ 1999;319:595
- Monica Ausejo, visiting fellowa,
- Antonio Saenz, visiting fellowa,
- Ba' Pham, statisticiana,
- James D Kellner, assistant professorb,
- David W Johnson, assistant professorb,
- David Moher, directora,
- Terry P Klassen, director, children's hospital ()a
- a Thomas C Chalmer's Center for Systematic Reviews, Children's Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, Ontario K1H 8LI, Canada
- b Department of Pediatrics, University of Calgary, Alberta Children's Hospital, 1820 Richmond Road, Calgary, Alberta T2T 5C7, Canada
- Correspondence to: TP Klassen Department of Pediatrics, University of Alberta, 2C3.67 Walter C Mackenzie Health Sciences Center, Edmonton, Alberta T6G 2R7
- Accepted 2 June 1999
Objective: To determine the effectiveness of glucocorticoid treatment in children with croup.
Design: Meta-analysis of randomised controlled trials that examine the effectiveness of glucocorticoid treatment in children with croup.
Main outcome measures: Score on scale measuring severity of croup, use of cointerventions (adrenaline (epinephrine), antibiotics, or supplemental glucocorticoids), length of stay in accident and emergency or in hospital, and rate of hospitalisation.
Results: Twenty four studies met the inclusion criteria. Glucocorticoid treatment was associated with an improvement in the croup severity score at 6 hours with an effect size of −1.0 (95% confidence interval −1.5 to −0.6) and at 12 hours −1.0 (−1.6 to −0.4); at 24 hours this improvement was no longer significant (−1.0, −2.0 to 0.1). There was a decrease in the number of adrenaline treatments needed in children treated with glucocorticoids: a decrease of 9% (95% confidence interval 2% to 16%) among those treated with budesonide and of 12% (4% to 20%) among those treated with dexamethasone. There was also a decrease in the length of time spent in accident and emergency (−11 hours, 95% confidence interval −18 to 4 hours), and for inpatients hospital stay was reduced by 16 hours (−31 to 1 hour). Publication bias seems to play a part in these results.
Conclusions: Dexamethasone and budesonide are effective in relieving the symptoms of croup as early as 6 hours after treatment. Fewer cointerventions are used and the length of time spent in hospital is decreased in patients treated with glucocorticoids.
Most trials evaluating the treatment of croup are of high methodological quality and hence have a low risk of bias
Publication bias, however, seems to be a problem, making the results of this meta-analysis somewhat less certain
Glucocorticoids seem to bring about clinical improvement in children with croup within 6 hours
Nebulised budesonide or dexamethasone, given either orally or intramuscularly, is effective in treating croup
The use of glucocorticoids is associated with a lower rate of use of cointerventions and shortens the time spent in hospital
Funding This review was supported in part by the Health Research Fund from the government of Spain: MA received FIS grant No 97/5407 and AS received FIS grant No 97/5408.
Competing interests DWJ received research funding from Astra Pharmaceuticals, the manufacturer of budesonide, to complete a trial comparing treatment with budesonide, dexamethasone, and placebo (reference w12 on the BMJ's website).
website extra References for the trials included and other additional information can be found on the BMJ's website www.bmj.com
- Accepted 2 June 1999