Letters
CRASH trial is based on problematic meta-analysis
BMJ 1999; 319 doi: https://doi.org/10.1136/bmj.319.7209.578 (Published 28 August 1999) Cite this as: BMJ 1999;319:578
- B Gregson, principal research associate,
- N V Todd, consultant anaesthetist, intensive care,
- D Crawford, consultant anaesthetist, intensive care,
- C J Gerbe, consultant neurosurgeon,
- B Fulton, consultant neurosurgeon,
- L Taccon, consultant neurosurgeon,
- P J Crawford, consultant neurosurgeon,
- R P Sengupta, consultant neurosurgeon
- Newcastle General Hospital, Acute Services, Newcastle upon Tyne NE4 6BE
EDITOR—Kmietowicz reports the start of the CRASH trial, a multicentre trial of steroids for treating head injury.1 The meta-analysis which forms the basis for the trial is a good example of how one small study can potentially expose thousands of patients to unnecessary risk. The dose of steroids used in CRASH (2 g methyl prednisolone over 1 …
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