Intended for healthcare professionals


Management of preterm labour

BMJ 1999; 319 doi: (Published 24 July 1999) Cite this as: BMJ 1999;319:257

Nifedipine in management of preterm labour is safe

  1. D N M Papatsonis, Resident (,
  2. H P van Geijn, Professor of obstetrics and gynaecology,
  3. G A Dekker, Professor of obstetrics and gynaecology
  1. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, Free University Hospital, Amsterdam, Netherlands
  2. Department of Obstetrics and Gynaecology, University of Adelaide (NWAHS), Adelaide, Australia
  3. Imperial College School of Medicine, Chelsea and Westminster Hospital, London SW10 9NH

    EDITOR—Steer and Flint stated in their article in the ABC of labour care that the use of sympathomimetics is generally the safest choice for the mother and the fetus and that calcium channel blockers cause significant hypotension.1 We disagree with this.

    In studies in pregnant women nifedipine has minimal cardiovascular and metabolic effects during clinical use, in contrast with β2 sympathomimetics such as ritodrine.2 Nifedipine in the management of preterm labour is associated with significantly fewer maternal side effects than ritodrine.3 4 In our study we never had to stop treatment in the …

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