Intended for healthcare professionals


What are leukotrienes and how do they work in asthma?

BMJ 1999; 319 doi: (Published 10 July 1999) Cite this as: BMJ 1999;319:90
  1. Abi Berger, science editor
  1. BMJ

    Acute asthma attacks are often triggered by allergens or exercise. Inflammatory molecules called leukotrienes are one of several substances which are released by mast cells during an asthma attack, and it is leukotrienes which are primarily responsible for the bronchoconstriction. In chronic, more severe cases of asthma, general bronchial hyperreactivity (or smooth muscle twitchiness) is largely …

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