Intended for healthcare professionals


Teaching patients with bipolar disorder to identify early symptoms of relapse

BMJ 1999; 318 doi: (Published 05 June 1999) Cite this as: BMJ 1999;318:1557

When were outcomes separated?

  1. Christopher Cates, General practitioner. (
  1. Manor View Practice, Bushey, Hertfordshire WD2 2NN
  2. University of Manchester Department of Community Psychiatry, Royal Preston Hospital, Preston, Lancashire PR2 9HT

    EDITOR—The decision to analyse the relapses for mania and depression separately in Perry et al's trial in patients with bipolar disorder is crucial.1 The reported power analysis was calculated for the overall (mania and depression) relapse rate, but no result is shown relating to the overall relapse rate. This raises the possibility that the decision to split the outcomes was taken later.

    The authors …

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