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Trial of prophylactic mastectomy is needed

BMJ 1999; 318 doi: (Published 05 June 1999) Cite this as: BMJ 1999;318:1556
  1. C Palmieri, Cancer Research Campaign clinical research fellow. (
  1. Cancer Research Campaign Laboratories, Imperial College School of Medicine-Charing Cross Campus, London W6 8RP

    EDITOR—I agree with Fentiman that all cases of prophylactic mastectomy should be centrally registered, but his proposals should go further to maximise the potential information from this group of women.1 The proposals should include compulsory testing of all women undergoing the operation for known mutations of the BRCA1 and BRCA2 genes; a central archive should be established for storing part of the mastectomy specimen, and a chemopreventive trial should be considered.

    The first measure is crucial to allow research …

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