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Efficacy of vitamin B-6 in the treatment of premenstrual syndrome:systematic review

BMJ 1999; 318 doi: https://doi.org/10.1136/bmj.318.7195.1375 (Published 22 May 1999) Cite this as: BMJ 1999;318:1375
  1. Katrina M Wyatt, non-clinical lecturer in reproductive endocrinology (mea10{at}keele.ac.uk)a,
  2. Paul W Dimmock, researchera,
  3. Peter W Jones, professorb,
  4. P M Shaughn O'Brien, professora
  1. aAcademic Department of Obstetrics and Gynaecology, North Staffordshire Hospital, Stoke on Trent ST4 6QG
  2. bDepartment of Mathematics, Keele University, Keele ST5 5BG
  1. Correspondence to: Dr Wyatt
  • Accepted 11 March 1999

Abstract

Objective: To evaluate the efficacy of vitamin B-6 in the treatment of premenstrual syndrome.

Design: Systematic review of published and unpublished randomised placebo controlled trials of the effectiveness of vitamin B-6 in the management of premenstrual syndrome.

Subjects: Nine published trials representing 940 patients with premenstrual syndrome.

Main outcome measures: Proportion of women whose overall premenstrual symptoms showed an improvement over placebo. A secondary analysis was performed on the proportion of women whose premenstrual depressive symptoms showed an improvement over placebo.

Results: Odds ratio relative to placebo for an improvement in overall premenstrual symptoms was 2.32 (95% confidence interval 1.95 to 2.54). Odds ratio relative to placebo for an improvement in depressive symptoms was 1.69 (1.39 to 2.06) from four trials representing 541 patients.

Conclusion: Conclusions are limited by the low quality of most of the trials included. Results suggest that doses of vitamin B-6 up to 100 mg/day are likely to be of benefit in treating premenstrual symptoms and premenstrual depression.

Footnotes

    • Accepted 11 March 1999
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