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Researchers discover “feedback loop” in allergic reactions

BMJ 1999; 318 doi: https://doi.org/10.1136/bmj.318.7194.1306-c (Published 15 May 1999) Cite this as: BMJ 1999;318:1306
  1. Scott Gottlieb
  1. New York

Researchers testing an experimental antiallergy drug think that they have discovered a new immunological feedback loop that is involved in the basic mechanism driving allergic reactions (Journal of Immunology 1999;162:5183-90).

The new biochemical loop links the amount of IgE antibody to the number of immune cell IgE receptors scattered on preformed immunological mediators such as those found in mast cells. …

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