Randomised controlled trials are importantBMJ 1999; 318 doi: https://doi.org/10.1136/bmj.318.7190.1074 (Published 17 April 1999) Cite this as: BMJ 1999;318:1074
- Geoff Venning, Consultant in pharmaceutical medicine
- Pharmaceutical Research Services, 14 Lucas Road, High Wycombe, Buckinghamshire HP13 6QG
EDITOR—Cranberg's arguments against controlled trials and in favour of historical controls supported by data on matching for known risk factors are seriously flawed.1 There are at least four fallacies.
Firstly, the matching procedures …