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Iceland breast cancer study questions the risk attributable to gene mutations

BMJ 1998; 317 doi: (Published 31 October 1998) Cite this as: BMJ 1998;317:1174
  1. Vicki Madden
  1. London

    The risk of breast cancer in carriers of the BRCA2 gene–one of the two major genes associated with the disease–may be lower in some populations than previously suggested, according to a study from Iceland.

    The Icelandic study (Lancet 1998;352:1337-9) estimated that the risk of breast cancer in those with the BRCA2 gene mutation is 37% at the age of 70. This was considerably lower than previous studies, such as the Ashkenazi Jewish study (New England Journal of Medicine 1997;336:1401-8), which showed …

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