Search for better inotropic drugs should continue

BMJ 1998; 317 doi: https://doi.org/10.1136/bmj.317.7156.476a (Published 15 August 1998) Cite this as: BMJ 1998;317:476
  1. John A Lee, Senior lecturer in pathology,
  2. David G Allen, Professor of physiology
  1. Medical School, Sheffield S10 2RX
  2. Department of Physiology, University of Sydney, Sydney, NSW 2006, Australia

    EDITOR—In their editorial on drug treatment in heart failure, Steeds and Channer state that “all clinical trials of positively inotropic drugs have either failed to improve symptoms or have increased mortality in heart failure.”1 Even if this statement is allowed, it is a generalisation too far to conclude that “drugs that increase the force of contraction of the failing heart result in increased mortality and…there should be a halt on further …

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