Intermittent low dose prednisolone is safe in rheumatoid arthritis

BMJ 1998; 316 doi: https://doi.org/10.1136/bmj.316.7144.1606a (Published 23 May 1998) Cite this as: BMJ 1998;316:1606
  1. Peter C Gøtzsche (p.c.gotzsche@cochrane.dk), Director,
  2. Helle Krogh Johansen, Senior researcher
  1. The Nordic Cochrane Centre, Rigshospitalet, Department 7112, Tagensvej 18 B, DK-2200 Copenhagen N, Denmark

    EDITOR—In our meta-analysis we concluded that doses of prednisolone of ≤15 mg daily may be used intermittently in patients with rheumatoid arthritis, particularly if the disease cannot be controlled by other means.1

    An accompanying editorial by Dennison and Cooper warned that doubts about the safety of this treatment remained.2 They also mentioned a number of side effects reported in a narrative review by Caldwell and Furst which we also cited in our meta-analysis (reference number 57). They complained that we had not subjected our …

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