Prevalence study of carcinoma in situ of testis in oligozoospermic men

BMJ 1998; 316 doi: https://doi.org/10.1136/bmj.316.7141.1387 (Published 02 May 1998) Cite this as: BMJ 1998;316:1387

Study was too small to show potential benefits of screening

  1. Ramesh Rajentheran,
  2. Joanne Kenworthy,
  3. Michael Cunnington, 4th year medical students
  1. Department of Epidemiology and Public Health, School of Health Sciences, Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH
  2. University Department of Growth and Reproduction, Rigshospitalet, DK 2100 Copenhagen, Denmark

    EDITOR—Giwercman et al evaluated the need for screening for carcinoma in situ of the testis in oligozoospermic men from infertile couples.1 They concluded that these men do not have an increased risk of carcinoma in situ, therefore implying that screening is not justified.

    Their study fails to provide the information required to form a proper judgment on the potential benefits of screening. Although no cases of carcinoma in situ of the testis were detected among the 207 men studied, the confidence intervals reported are compatible with a prevalence of almost 18 in every 1000 men and a relative risk 4.6 times that in the general population. This represents a significantly increased risk. To put this in context, the detection rate for breast cancer in the first wave of the NHS breast screening …

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