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Melanoma vaccines show promise

BMJ 1998; 316 doi: (Published 14 March 1998) Cite this as: BMJ 1998;316:797
  1. Deborah Josefson
  1. San Francisco

    Two vaccines developed to fight melanoma have shown promise in early clinical trials. The vaccines were used in patients with advanced disease and work by enhancing a patient's immune response to the tumours.

    A team led by Dr Steven Rosenberg of the National Cancer Institute in the United States constructed a vaccine based on gp100, a particularly immunogenic protein displayed on the surface of melanoma cells (Nature Medicine 1998;4:269-70). This was injected into 31 patients with metastatic melanoma who were subsequently treated with interleukin 2, a T …

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