New obesity mediator is discovered

BMJ 1998; 316 doi: (Published 28 February 1998) Cite this as: BMJ 1998;316:645
  1. Deborah Josefson
  1. San Francisco

    Scientists at the University of Texas have uncovered a new hormonal cascade that is concerned with the regulation of feeding behaviour. The discovery may eventually lead to new drug treatment for obesity, diabetes, and cachexia.

    The researchers identified centrally acting neuropeptides and their associated receptors, which they named orexin A and B and OX-1R and OX-2R respectively (Cell 1998; 92:573-83). The orexins are produced in the lateral hypothalamus, an area of the brain known to be concerned with the sensation …

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