Choice of bone marrow donors could improve

BMJ 1998; 316 doi: (Published 21 February 1998) Cite this as: BMJ 1998;316:571
  1. Abi Berger
  1. London

    The identification of the DNA structure of a cell surface antigen may help to improve the selection of suitable donors of bone marrow transplants.

    Despite careful matching of donors and recipients, up to 30% of people who undergo sibling bone marrow transplants suffer severe graft versus host disease. The disease occurs when donor cytotoxic T lymphocytes attack host organs such as the skin, gut, and liver, and it can be fatal. Immunologists in the Netherlands and the United States have identified the DNA structure of a cell surface antigen, which is the only one so far recognised to correlate with the development of …

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