Aspirin and warfarin best for primary prevention of heart attacks

BMJ 1998; 316 doi: (Published 31 January 1998) Cite this as: BMJ 1998;316:327
  1. Zosia Kmietowicz
  1. London

    Combined treatment with warfarin and aspirin reduces the incidence of ischaemic heart disease and prevents more deaths from myocardial infarction among men at high risk than either agent on its own, according to results of the thrombosis prevention trial.

    More than 5000 men aged 45–69 years took part in the Medical Research Council's general practice based study (Lancet 1998;351:233-41). They were randomly assigned to receive low intensity oral warfarin (4.1 mg a day on average) and aspirin (75 mg daily), active warfarin and placebo aspirin, active aspirin and placebo warfarin, or a placebo for both …

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