Insulin dependent diabetes is probably due to environmental effect during childhood

BMJ 1997; 315 doi: https://doi.org/10.1136/bmj.315.7114.1017a (Published 18 October 1997) Cite this as: BMJ 1997;315:1017
  1. R D G Leslie, Reader in diabetesa,
  2. D A Pyke, Honorary consultant physiciana
  1. a Department of Diabetes, St Bartholomew's Hospital, London EC1A 7BE

    Editor—Petersen et al report autoantibodies associated with insulin dependent diabetes mellitus in a set of monozygotic and dizygotic Danish twin pairs in which one or both twins had diabetes.1 We have similar results from a study of British twins collected over 30 years. We studied antibodies to islet cells, glutamic acid decarboxylase, and the novel antigen protein tyrosine phosphatase.2 We did not study insulin antibodies, because in insulin treated patients they cannot be designated autoantibodies. Eighteen pairs of monozygotic twins …

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