Intended for healthcare professionals


Any questions: Why does HIV infection progress to AIDS?

BMJ 1997; 315 doi: (Published 30 August 1997) Cite this as: BMJ 1997;315:f
  1. Brian Gazzard, consultant physician
  1. London

    The answer to this deceptively simple question has aroused controversy,1 much of it clarified recently. From the beginning of the epidemic it was clear that progression to AIDS was marked by the development of opportunistic infections or tumours, associated with immunological failure and T4 cell lymphocyte depletion. Overwhelming epidemiological evidence showed that a retrovirus, …

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