Genetic engineering reverses antibiotic resistance

BMJ 1997; 315 doi: (Published 16 August 1997) Cite this as: BMJ 1997;315:383
  1. Kamran Abbasi
  1. BMJ

    Researchers have developed a genetic engineering technique that for the first time allows drug resistant bacteria to be rendered drug sensitive. This may prove to be a cheaper method of negating antibiotic resistance than the current approach of developing new drugs.

    A team of biologists from Yale University in the United States, led by Nobel prize winner Professor Sidney Altman, has used plasmids that contain synthetic genes coding for small oligoribonucleotides, called external guide sequences (EGSs), to infiltrate drug resistant strains of Escherichia coli (Proceedings of the National …

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