Quoting intermediate analyses can only mislead

BMJ 1997; 314 doi: https://doi.org/10.1136/bmj.314.7098.1907a (Published 28 June 1997) Cite this as: BMJ 1997;314:1907
  1. J M Bland, Professor of medical statisticsa
  1. a St George's Hospital Medical School, London SW17 0RE

    Editor—Marion E T McMurdo and colleagues report a trial of exercise in relation to bone density and falls.1 They state that “The difference between the groups in the number of women falling during the whole two year period was not significant (P=0.158), but between 12 months and 18 months into the study the difference was significant (P=0.011).” If in a clinical trial we carry out …

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