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Large pragmatic randomised studies of new antiepileptic drugs are needed

BMJ 1997; 314 doi: (Published 14 June 1997) Cite this as: BMJ 1997;314:1764
  1. Anthony Marson, Lecturer in neurologya,
  2. Zakaria Kadir, Honorary senior registrara,
  3. David Chadwick, Professor of neurologya
  1. a Walton Centre for Neurology and Neurosurgery, University of Liverpool, Liverpool L9 1AE

    Editor—Two letters commenting on our systematic review of trials of new antiepileptic drugs1 deserve a response. We agree with A J A Elferink and B J Van Zwieten-Boot that the number needed to treat is a useful statistic, but we believe that they are wrong to suggest that we should have presented it rather than odds ratios.2 We had in fact undertaken a risk difference analysis (1/number needed to treat) and found much greater heterogeneity with …

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