Protein marker linked with poor cancer outcome

BMJ 1997; 314 doi: (Published 01 February 1997) Cite this as: BMJ 1997;314:323
  1. Susan Mayor
  1. London

    There are new hopes of a reliable indicator for the aggressiveness of tumour cells as three independent studies show that low amounts of p27–a protein that inhibits the cell cycle–are associated with poor survival in breast and colorectal carcinoma.

    All three studies were reported in this month's Nature Medicine (1997;3:222-5;227-30;231-4). One study of 168 cases of primary breast cancer showed that low nuclear expression of p27 was a significant predictor of poor disease free survival. Researcher Dr Joyce Slingerland, …

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