Intended for healthcare professionals

Rapid response to:

Clinical Review

Science, medicine, and the future: Molecular genetic approaches to understanding disease

BMJ 1997; 314 doi: (Published 11 January 1997) Cite this as: BMJ 1997;314:126

Rapid Response:

Re: Science, medicine, and the future

The technology for animal-human chimeras, human embryo cloning, animal implantation of human embryos, exists for more than a decade. [3][4][5]
Nowadays, CRISPR-cas9 gene editing can quickly and successfully manage to engineer genetically modified farm animals that lack uterine/leucocytic surface proteins which induce rejections/abortions of xenographic embryos.
Several receptor mechanisms, specific for major histocompatibility complex, tolerize fetal antigen-specific maternal CD4⁺ T cells and CD8⁺ T cells, excluding fetal rejection, which can be effectively targeted. [6][7][8][9][10]
Only ethical dilemmas prevent embryonic gestational surrogacy into animal uteri. [1][2]

Competing interests: No competing interests

01 June 2016
Stavros Saripanidis
Consultant in Obstetrics and Gynaecology
Thessaloniki, Greece