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Absence of oats toxicity in adult coeliac disease

BMJ 1996; 313 doi: (Published 23 November 1996) Cite this as: BMJ 1996;313:1300
  1. Usha Srinivasan, clinical registrara,
  2. Niamh Leonard, clinical registrarb,
  3. Eileen Jones, laboratory technicianb,
  4. Donald D Kasarda, research chemistc,
  5. Donald G Weir, regius professor of physicsd,
  6. Cliona O'Farrelly, director of research laboratorye,
  7. Conleth Feighery, associate professor of immunologya
  1. a Department of Immunology, St James's Hospital, Dublin 8, Republic of Ireland
  2. b Department of Histopathology, St James's Hospital, Dublin
  3. c US Department of Agriculture, Albany CA 94710, USA
  4. d Department of Gastroenterology, St James's Hospital and Trinity College, Dublin
  5. e Education and Research Centre, St Vincent's Hospital, Elm Park, Dublin
  1. Correspondence to: Professor Feighery.
  • Accepted 18 July 1996

Coeliac disease is a gluten-sensitive disorder characterised by malabsorption and a typical histological lesion. Treatment with a strict gluten-free diet results in complete clinical and histological recovery. The conventional gluten-free diet used to treat coeliac disease proscribes oats cereal as well as wheat, barley, and rye.1 However, the issue of oats toxicity has not been conclusively resolved, and the prohibition of this important cereal deprives patients of a valuable source of fibre and nutrients. The aim of this study was to examine the clinical, histological, and immunological responses of adult patients with coeliac disease to challenge with oats.

Patients, methods, and results

Ten adult patients with coeliac disease in clinical and histological remission were recruited from the coeliac outpatient clinic in St James's Hospital, Dublin. Each patient …

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