Switching off ovaries benefits women with breast cancer

BMJ 1996; 313 doi: (Published 09 November 1996) Cite this as: BMJ 1996;313:1167

The 100 year old practice of ovarian ablation for treating early breast cancer significantly improves long term survival in premenopausal women, according to an international study of over two thousand women. Oncologists warn, however, that symptoms arising from the resulting early menopause should not be underestimated.

The Early Breast Cancer Trialists' Collaborative Group carried out a meta-analysis of 12 previous trials begun before 1980 (Lancet 1996;348:1189-96). These included 2102 women …

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