Fall in total cholesterol concentration over five years in association with changes in fatty acid composition of cooking oil in Mauritius: cross sectional survey
BMJ 1996; 313 doi: https://doi.org/10.1136/bmj.313.7064.1044 (Published 26 October 1996) Cite this as: BMJ 1996;313:1044
- Ulla Uusitalo, research nutritionista,
- Edith J M Feskens, senior epidemiologistb,
- Jaakko Tuomilehto, professora,
- Gary Dowse, senior epidemiologistc,
- Ulan Haw, research nutritionistd,
- Djamil Fareed, WHO representativee,
- Farodjeo Hemraj, principal biochemistd,
- Hassam Gareeboo, project managerd,
- K George M M Alberti, professorf,
- Paul Zimmet, directorc
- a National Public Health Institute, Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, Mannerheimintie 166, FIN-00300 Helsinki, Finland
- b National Institute of Public Health and the Environment, Department of Chronic Disease and Environmental Epidemiology, 3720 Bilthoven, Netherlands
- c International Diabetes Institute, Melbourne, Australia
- d Ministry of Health, Port Louis, Mauritius
- e World Health Organisation, Port Louis, Mauritius
- f Human Diabetes and Metabolism Research Centre, University of Newcastle upon Tyne, Newcastle upon Tyne
- Correspondence to: Dr Tuomilehto.
- Accepted 20 August 1996
Abstract
Objective: To determine the extent to which reducing the saturated fatty acid composition of a ubiquitously used cooking oil influenced changes in cholesterol concentration in the population during a five year intervention programme in Mauritius.
Design: Cross sectional surveys in 1987 and 1992 determined mean total cholesterol concentrations in the population. A random sample of respondents in the 1992 survey completed a nutrition questionnaire that included questions on diet in the previous 24 hours.
Setting: Mauritius.
Intervention: In 1987 the government of Mauritius changed the composition of the commonly used cooking oil from being mostly palm oil (high in saturated fatty acids) to being wholly soya bean oil (high in unsaturated fatty acids).
Subjects: 5080 and 5162 subjects in 1987 and 1992 cross sectional surveys. 2059 subjects aged 30–64 years were randomly selected from the respondents of the 1992 survey to take part in the nutrition survey
Main outcome measures: Fatty acid composition of phospholipids in pooled serum samples from men and women from the two surveys; measured and predicted change in serum cholesterol concentration.
Results: From 1987 to 1992 total cholesterol concentrations fell significantly by 0.79 mmol/l (P<0.001) in men and 0.82 mmol/l (P<0.001) in women. The estimated intake of saturated fatty acids decreased by 3.5% of energy intake in men and by 3.6% in women, and the intake of polyunsaturated fatty acids increased by 5.5% and 5.6% of energy intake, respectively. These changes were reflected in changes in the fatty acid composition of serum phospholipids, and according to Keys' formula these changes explained much of the decrease in serum cholesterol concentrations (predicted decrease of 0.38 mmol/l in men and by 0.40 mmol/l in women).
Conclusion: Dietary changes that entailed a reduction in the saturated fat content of a ubiquitous cooking oil explained most of the observed decrease in serum cholesterol concentration over five years in the population of Mauritius.
Key messages
The saturated fatty acid intake of Mauritians was reduced by modifying the composition of the widely used cooking oil
Mean serum cholesterol concentration decreased by 15% after the cooking oil intervention was introduced nationwide
Effective, low cost prevention programmes for chronic disease are needed in less industrialised countries. Simple action in dietary policy could be one such strategy
Footnotes
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Funding Supported by grant DK 25446 from the United States National Institute of Diabetes and Digestive and Kidney Diseases and by the British Diabetic Association and the Academy of Finland.
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Conflict of interest None.
- Accepted 20 August 1996