N of 1 trials

BMJ 1996; 313 doi: https://doi.org/10.1136/bmj.313.7054.427b (Published 17 August 1996) Cite this as: BMJ 1996;313:427

Research is needed into why such trials are not more widely used

  1. Miquel Porta,
  2. Francisco Bolumar,
  3. Ildefonso Hernandez,
  4. Jesus Vioque
  1. Associate professor Institut Municipal d'Investigacio Medica, Universitat Autonoma de Barcelona, E-08003 Barcelona, Spain
  2. Professor Associate professor Associate professor Department of Public Health, Universidad de Alicante, 03080-Sant Joan, Alicante, Spain

    EDITOR,—Ten years after n of 1 trials were discovered for medicine by clinical epidemiologists from McMaster University,1 2 Jeffrey Mahon and colleagues' study on theophylline for irreversible chronic airflow limitation merits several comments.3 The authors cautiously state that further studies are needed before widespread use of n of 1 trials can be advocated in routine clinical practice. In 1986 we also wondered what the relevance of the contributions of this design to patients' care would be.4 In view of the …

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